Green Goblin (Earth-1610)

Norman Osborn was a scientist turned criminal who had been mutated into the monstrous Green Goblin, and was one of Spider-Man's greatest enemies.

Biography
Norman Osborn was an unscrupulous industrialist and biologist who, at one point, underwent an experiment that horribly mutated him into a massive dragon/goblin-esque monster. He soon came into conflict with the superhero Spider-Man, and became one of his greatest foes as the super-villain Green Goblin. Under unknown circumstances, he was employed into service to the villainous crime boss Wilson Fisk, aka the Kingpin, something he notes he didn't have a choice over.

In the following years, Kingpin commissioned the Super-Collider, a particle accelerator-esque machine that could open portals to different dimensions, designed and created by Dr. Olivia Octavius. Osborn was in on this, and when Spider-Man caught wind of this scheme, he engaged the Green Goblin in the bunker where the Collider was located. As the two fought, Spider-Man tried to reason with Goblin over the dangers the Collider posed, particularly that it could open a black hole under New York. Goblin only noted it wasn't up to him, aggravated at Spidey's interference.

Unbeknownst to them, a boy named Miles Morales, whom had obtained similar superpowers, had stumbled upon their battle. Their destructive brawl put Miles in danger, and after being knocked off a platform, Spider-Man saved him.

Later, Fisk's second enforcer, the Prowler, engaged Spider-Man as well, as they fought across the Collider's chamber. As Fisk activated the machine, Goblin made a final attempt to kill Spider-Man by forcing him into the colliding energy beams, which caused it to malfunction, resulting in a huge explosion that caused a disruption across the multiverse, opening portals in other dimensions that pulled several alternate spider-themed heroes into their universe. The damage done to the Collider caused debris to crush Goblin underweight, killing him. However, his actions wounded Spider-Man, who was finished off by Kingpin, therefore in death, Osborn succeeded in defeating his nemesis.